Giuliana & Bill, Boy or Girl?

The season opens with some tragic news - Giuliana is facing breast cancer. How will she face this battle?

Giuliana and Bill are faced with a huge challenge to their conception - can they overcome it and how will it affect their lives?

Giuliana and Bill face huge life choices this week and retreat to consider them all from a distance.

Giuliana has a double mastectomy - will she recover? Plus, the couple face a life-changing phone call.

Giuliana receives news about her health issues, while Bill shares baby news with friends and family.

Giuliana and Bill look at less conventional routes for getting pregnant - will they find something that works for them?

Bill meets another Bill - in the form of a Clinton. How will their speech go down? Meanwhile, Giuliana returns to work after her mastectomy.

It's time for Giuliana and Bill to go home hunting - can they find their perfect pad in Chicago?

The Grammy's dominate Giuliana's schedule - can she keep up with it? Meanwhile, Bill goes back to Haiti to build a house.

The restaurant opening is upon Giuliana and Bill - how will they manage with the transition?

Will a trip to Cabo distract Giuliana from deeper concerns about her health issues?

Giuliana and Bill are looking forward to welcoming their new baby - which means a new house to match. Can they find the perfect residence?

Baby excitment builds for Giuliana and Bill this week - will they throw the perfect baby shower for friends and family?

Giuliana freaks out about her impending parenthood with the belief that she makes babies cry. Elsewhere, the couple tries to find the perfect nurse.

Hey baby! Giuliana and Bill redecorate their home in preparation for their newborn. And in Chicago, there's another home search on the agenda for Bill.

Giuliana is stressed about losing her Momjo when she has the baby. Meanwhile, there is a redesign in store for the Rancic's LA home.

A break in Colorado provides Giuliana and Bill with the opportunity to reconnect. And the big day is imminent as they wait for the birth of their baby boy.

It's the big day! Giuliana and Bill rush from their babymoon in Vail to Denver where their child is finally born.

It's the exciting time that Giuliana and Bill have been waiting for - the birth of baby Duke! He meets the family, while the couple adjust to parenthood.

Giuliana and Bill adjust to life as new parents and prepare for their baby's first photo shoot.

Bill is left to deal with Duke during a work trip - can he handle it? And how will Giuliana deal with being away from her son?

There are delays during the family move! Duke's baptism adds pressure to Giuliana and Bill as they try to figure out who will be godparents.

As the season draws to an end, Giuliana and Bill finalize their plans for baby number two. And we find out if G has what it takes to be a rock star!