Most Extreme Humans, Upside Down with a Twist

S1 E1 • 43m • HDPG

Mark's hands are 20 times bigger than a normal adult male's. After learning that his condition may require amputation, Mark stopped seeing doctors. Now troubling changes to his hands means he must go back. If not for himself, then for his young daughter.

S1 E2 • 44m • HDPG

Winner of the Uganda's Ugliest Man contest, Godfrey has a rare disorder that has left him disfigured. With 10 children, a new baby on the way, and his condition worsening, he is seeking medical answers that will determine his future.

S1 E3 • 44m • HDPG

In Brazil, Claudio lives with a condition that bent his head backward. Ahead of his 50th birthday, he wants to climb a sacred mountain. In Norway, Birgitte lives with a different presentation of the same condition. She's training for the next Paralympics.